Synthesis and Antifungal Activities of 2-Hydroxy-4,6-Substituted Phenyl Pyrimidine

Flavones and chromanones are known to be biologically important compounds over 4000 chemically unique flavanoids have been identified in plant sources. These low-molecular-weight substances, found in all vascular plants, with an assortment of basic structure of phenyl benzopyrones (phenyl chromones). In the present work 2-hydroxy pyrimidine and 2-mercapto pyrimidine were prepared from phenol i.e. o-chlorophenol as a starting material. The compounds were characterized on the basis of elemental analysis their IR, 1HNMR and screened for their antifungal activity. Some of these compounds showed significant antifungal activity. The activity was correlated with the structure.